Glenn Dranoff Selected Research

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

12/2022	GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized, double-blinded, phase 2 trial.
12/2022	Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model.
7/2022	The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II-III and metastatic breast cancers.
1/2019	GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.
1/2018	PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF.
10/2017	Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection.
7/2015	Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines.
3/2015	Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions.
3/2014	Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants.
3/2014	Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity.

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Glenn Dranoff Research Topics

Disease

101	Neoplasms (Cancer) 12/2022 - 02/2002
25	Melanoma (Melanoma, Malignant) 03/2018 - 05/2002
10	Lung Neoplasms (Lung Cancer) 01/2017 - 03/2003
8	Leukemia 12/2022 - 10/2002
8	Neoplasm Metastasis (Metastasis) 01/2022 - 05/2002
7	Inflammation (Inflammations) 01/2022 - 05/2003
6	Glioma (Gliomas) 04/2018 - 03/2006
5	Prostatic Neoplasms (Prostate Cancer) 12/2022 - 03/2003
5	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2022 - 02/2002
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 02/2009
5	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 01/2009
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2018 - 05/2002
5	Ovarian Neoplasms (Ovarian Cancer) 02/2014 - 03/2003
4	Disease Progression 07/2022 - 11/2008
4	Infections 10/2017 - 10/2006
4	Colorectal Neoplasms (Colorectal Cancer) 12/2016 - 12/2010
4	Necrosis 08/2011 - 04/2003
3	Breast Neoplasms (Breast Cancer) 07/2022 - 03/2009
3	Adenocarcinoma of Lung 01/2019 - 08/2015
3	Multiple Myeloma 01/2019 - 01/2004
3	Carcinoma (Carcinomatosis) 12/2016 - 04/2003
3	Experimental Melanoma 03/2014 - 02/2002
2	Injection Site Reaction 12/2022 - 11/2017
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021 - 01/2020
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 01/2006
2	Hypersensitivity (Allergy) 07/2017 - 01/2016
2	Cytokine Release Syndrome 12/2016 - 04/2015
2	Glioblastoma (Glioblastoma Multiforme) 02/2016 - 11/2014
2	Myeloid Leukemia (Leukemia, Myelocytic) 03/2015 - 03/2011
2	Renal Cell Carcinoma (Grawitz Tumor) 09/2012 - 02/2009
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2002 - 05/2002
1	Colitis 01/2022
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019
1	Chagas Disease (American Trypanosomiasis) 01/2019
1	Leishmaniasis 01/2019

Drug/Important Bio-Agent (IBA)

37	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2022 - 02/2002
34	VaccinesIBA 12/2022 - 05/2002
24	AntibodiesIBA 01/2021 - 05/2002
23	CytokinesIBA 01/2021 - 05/2003
22	AntigensIBA 01/2021 - 02/2002
14	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2003
9	Biological ProductsIBA 01/2019 - 04/2003
8	LigandsIBA 01/2020 - 06/2006
8	Neoplasm Antigens (Tumor Antigens)IBA 04/2015 - 10/2002
8	Complementary DNA (cDNA)IBA 03/2015 - 05/2002
7	Cancer VaccinesIBA 12/2022 - 02/2002
5	Biomarkers (Surrogate Marker)IBA 04/2018 - 12/2010
5	CTLA-4 AntigenIBA 06/2012 - 04/2003
4	micaIBA 01/2022 - 06/2006
4	InterferonsIBA 12/2020 - 05/2003
4	Interleukin-3 (Interleukin 3)IBA 01/2019 - 10/2006
4	Immune Checkpoint InhibitorsIBA 02/2016 - 08/2011
4	Staphylococcal Protein A (Protein A)IBA 02/2009 - 06/2006
4	Monoclonal AntibodiesIBA 01/2009 - 10/2002
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 03/2014
3	Inhibitor of Apoptosis ProteinsIBA 01/2018 - 03/2003
3	Peptides (Polypeptides)IBA 01/2017 - 03/2003
3	Pharmaceutical PreparationsIBA 01/2017 - 12/2011
3	IpilimumabIBA 01/2017 - 08/2011
3	AutoantibodiesIBA 03/2014 - 10/2002
3	milk fat globuleIBA 06/2009 - 04/2008
2	Tacrolimus (Prograf)FDA LinkGeneric 12/2022 - 11/2017
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2019
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 02/2008
2	Chimeric Antigen ReceptorsIBA 01/2020 - 01/2018
2	NK Cell Lectin-Like Receptor Subfamily KIBA 01/2020 - 03/2018
2	Complement System Proteins (Complement)IBA 01/2019 - 06/2006
2	Interleukin-5 (Interleukin 5)IBA 01/2019 - 06/2009
2	Interleukin-2 (IL2)IBA 01/2018 - 04/2015
2	Interferon-gamma (Interferon, gamma)IBA 10/2017 - 05/2003
2	B7-H1 AntigenIBA 01/2017 - 02/2016
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 06/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 12/2010
2	Polycomb Repressive Complex 2IBA 01/2017 - 01/2017
2	sipuleucel-T (APC8015)FDA Link 01/2016 - 08/2011
2	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 03/2008
2	SuspensionsIBA 07/2015 - 02/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2014 - 09/2010
2	PolymersIBA 03/2014 - 02/2009
2	EnzymesIBA 06/2012 - 03/2003
2	Integrin beta3 (GPIIIa)IBA 06/2009 - 11/2008
2	AutoantigensIBA 06/2008 - 10/2002
1	Methotrexate (Mexate)FDA LinkGeneric 12/2022
1	Tumor Viral Antigens (Large T Antigen)IBA 12/2022
1	Metalloproteases (Metalloproteinases)IBA 01/2022
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2022
1	Chemotactic FactorsIBA 01/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	Protein Isoforms (Isoforms)IBA 03/2019
1	Antigen Receptors (Antigen Receptor)IBA 01/2019
1	ArginaseIBA 01/2019

Therapy/Procedure

33	Immunotherapy 01/2021 - 10/2002
32	Therapeutics 12/2020 - 05/2003
4	Hematopoietic Stem Cell Transplantation 03/2015 - 10/2002
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/2011 - 02/2002
2	Radiotherapy 01/2016 - 06/2009
2	Ligation 03/2014 - 06/2012
2	Drug Therapy (Chemotherapy) 03/2012 - 06/2009
1	Heterologous Transplantation (Xenotransplantation) 01/2021